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The SIOP LGG 2004 patient requirement for recruitment to the randomization between vincristine / carboplatin vs vincristine / carboplatin / etoposide induction therapy has been fulfilled. We are working to complete the trial datasets for analysis and must wait for the patient follow up to mature. The study remains open for registration of all patients meeting the study criteria. The patients who were previously eligible for the randomization should be treated according to the standard induction arm vincristine / carboplatin.

	The International Research Consortium on childhood low grade glioma research (ICLGG) represents the LGG strategy group of the Brain Tumor Sub-Committee of the International Society of Pediatric Oncology (SIOP). This web site is dedicated to the SIOP-LGG 2004 trial that represents the second generation of clinical trials run by this consortium. The contribution of the major European Pediatric Neuro-oncology Groups to the study has made possible to conceive a prospective randomised trial as part of the protocol. This is the first prospective randomised trial ever run in Europe on childhood LGG and the second in the world.
last update 19/01/2006

International Data Centre Clinical Trials & Biostatistic Unit Istituto Oncologico Veneto I.R.C.C.S. Busonera Hospital Via Gattamelata 64 35128 Padova,ITALY tel: 0039-049-8215704 fax: 0039-049-8215706 siop-lgg2004@ioveneto.it
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With partial support of a research grant from the private foundation "Città della Speranza" - Italy